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Monday, April 20, 2015

MISCARRIAGE AND SPERM ANTIBODIES

Woman has 4 miscarriages in 18 months before discovering the role of antigens
You would think that someone who works in the "fertility industry" would know everything about every treatment.  I know people may jokingly say "I'm allergic to my husband", but in this case, she really was!
 This article talks about an embryologist who was experiencing repeated miscarriages and tried an experimental treatment which may have been the answer to her problems. Read more:

SEE ALSO: 10 THINGS TO KNOW ABOUT MISCARRIAGE (getpregnantover40.com)

From the article:

"It was a controversial treatment that she had. She was immunised with her husband's white blood cells, in many ways making her allergic to her husband.

"Some people say it doesn't work but my view is that there are so many different causes for miscarriage so there is no one treatment that will work for everybody.

"The key is appropriate detailed investigations to identify the problem."

Antigens

He said that tests carried out at a specialist clinic in London revealed that Mrs Berrisford and her husband both carried similar antigens in their blood.

For this reason, her body was not producing the blocking antibodies to provide a protective blanket around the embryo and prevent the baby from being rejected.

Her immune system was not working properly so each time she became pregnant the baby miscarried. Mrs Berrisford said that she had been trying for a baby since November 2002 and had four miscarriages in 18 months.


from 
www.dailymail.co.uk

Friday, April 17, 2015

ONE WOMAN'S MISCARRIAGE STORY


Miscarriage, Your Thoughts And Feelings

Here is one woman's insightful account of what happened to her physically and emotionally as she went through the joy of finding out she was pregnant and then the stark realization that she was miscarrying. I could relate to so much that she had to say in this article. Read more:

SEE ALSO: MISCARRIAGE OVER 40

From the article:
 
I wouldn’t give up the experience of being pregnant for the newest, full-price shoes. I wouldn’t trade my inflated body for the tight, thin one I owned only a few months ago. I wouldn't sacrifice my Friday nights snoring on the sofa for the most epic of underground parties. While I miss my friends dearly, I know that the ones that are true will stick, no matter how far away we are. And no matter how hard it hurt, I wouldn’t give up the pain and hurt of the miscarriage for anything, because it made us realize just how much we loved.

There was nothing I wouldn’t give up in order to hear the sound of the little guy in my belly. We heard it and we cherished it. We hadn’t missed it this second time around. It sounded like I had a butterfly caught inside me, its wings beating against the walls. Patience, little one. You’re not big enough to come out yet.

from: 

www.hipmama.com

Tuesday, April 14, 2015

CAN EMF'S CONTRIBUTE TO MISCARRIAGE?

Miscarriage and Recurrent Miscarriage

There has been a longstanding debate about whether or not EMF's (electromagnetic fields) can negatively affect a pregnancy to the point of miscarriage. Some studies dismiss this as a risk, however other studies aren't so sure. Here is an article about monitoring EMF's in pregnant women and their risk of miscarriage:

From the article:

But the researchers did detect a connection when they looked at the highest level of EMFs that women were exposed to during the day. Women with a peak EMF exposure of 16 milligauss--much more intense than what most electrical appliances emit--were 80% more likely to have a miscarriage than women with lower peak exposures. This risk ``barely changed'' after the researchers accounted for about 30 known miscarriage risk factors. 

See Also:  Detoxify Your Environment If You're Trying To Conceive and To Avoid Miscarriage (www.getpregnantover40.com)

This risk was highest during the first 10 weeks of pregnancy and it was more pronounced in women with a history of miscarriage or problems becoming pregnant.

The investigators also found that the link between peak EMF exposure and the risk of miscarriage was stronger in women who engaged in their typical daily activities on the day they wore the EMF monitor, meaning the measurements were more likely to reflect their actual exposure. 

From  preventdisease.com

Saturday, April 11, 2015

HERPES AND MISCARRIAGE

Herpes and Miscarriage

If you think you might have a herpes infection, of course you should see your doctor as soon as possible.
 Herpes is something that should be monitored in pregnancy and for delivery. Here is a site which addresses Herpes in pregnancy and when it might affect the fetus:

Situations in which the developing fetus may be at risk:

A severe first episode during the first trimester (12 weeks) of pregnancy, which can lead to miscarriage. 

See Also: Natural Remedies For Miscarriage (www.getpregnantover40.com)

A first episode in the last trimester of pregnancy, when there is a large amount of virus present and insufficient time for the mother to produce antibodies to protect the unborn baby

If a woman has primary herpes (her first encounter with the virus) at any point in the pregnancy, there is the possibility of the virus crossing the placenta and infecting the baby in the uterus (about 5% of cases).

Mothers who acquire genital herpes in the last few weeks of pregnancy are at the highest risk of transmitting the virus.

To be infected with herpes in the last few weeks of pregnancy is rare but it may account for almost 50% of all cases of neo-natal herpes.

If the infection is a true primary (no previous antibodies to either HSV-1 or HSV-2), and a mother becomes HSV positive at the end of pregnancy, the risk of transmission can be as high as 50%. The risk is also higher if a mother has prior infection with HSV-1, but not HSV-2.


from: www.herpes-coldsores.com

Wednesday, April 08, 2015

CHROMOSOME TESTING FOR MISCARRIAGE



Pregnancy Loss and Chromosome Testing for Miscarriages

Guest Post By Melissa Maisenbacher


Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is actually quite common, with 10-25% of recognized pregnancies ending in miscarriage. If you have suffered a pregnancy loss or are currently in the process of having a miscarriage, you may be wondering what caused the loss and worry about whether it will happen again. This article aims to answer the following questions:

  • What causes miscarriage?
  • How common is pregnancy loss?
  • What type of genetic testing is available for miscarriage tissue?
  • How can chromosome testing help?

Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most common cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities - extra or missing whole chromosomes, also called "aneuploidy" - occur because of a mis-division of the chromosomes in the egg or sperm involved in a conception. Typically, humans have 46 chromosomes that come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a baby to develop normally it is essential that it have exactly the right amount of chromosome material; missing or extra material at the time of conception or in an embryo or fetus can cause a woman to either not become pregnant, miscarry, or have a baby with a chromosome syndrome such as Down syndrome.

Over 50% of all first trimester miscarriages are caused by chromosome abnormalities. This number may be closer to 75% or higher for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep increase in women older than 35.

Pregnancy Loss - How Common is it?

Miscarriage is far more common than most people think. Up to one in every four recognized pregnancies is lost in first trimester miscarriage. The chance of having a miscarriage also increases as a mother gets older.

Most women who experience a miscarriage go on to have a healthy pregnancy and never miscarry again. However, some women seem to be more prone to miscarriage than others. About five percent of fertile couples will experience two or more miscarriages.

Of note, the rate of miscarriage seems to be increasing. One reason for this may be awareness - more women know they are having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas in the past the miscarriage would have appeared to be just an unusual period. Another reason may be that more women are conceiving at older ages.

Types of Genetic Testing Helpful for Miscarriages

Genetic testing actually refers to many different types of testing that can be done on the DNA in a cell. For miscarriage tissue, also called products of conception (POC), the most useful type of test to perform is a chromosome analysis. A chromosome analysis (also called chromosome testing) can examine all 23 pairs of chromosomes for the presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue can often identify the reason for the pregnancy loss.

The most common method of chromosome analysis is called karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, a process called "cell culture". Because of this requirement, tissue that is passed at home is often unable to be tested with this method. About 20% or more of miscarriage samples fail to grow and thus no results are available. Additionally, karyotyping is unable to tell the difference between cells from the mother (maternal cells) and cells from the fetus. If a normal female result is found, it may be the correct result for the fetus or it may be maternal cell contamination (MCC) in which the result actually comes from testing the mother's cells present in the pregnancy tissue instead of the fetal cells. MCC appears to occur in about 30% or more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months to come back from the laboratory.

Microarray testing is a new type of genetic testing done on miscarriage samples; the two most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also able to test all 23 pairs of chromosomes for aneuploidy, but does not require cell culture. Therefore, you are more likely to receive results and the results are typically returned faster when microarray testing is used. Additionally, some laboratories are collecting a sample of the mother's blood at the same time the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing - How can it help?

If a chromosome abnormality is identified, the type of abnormality found can be assessed to help answer the question: "Will this happen to me again?". Most of the time, chromosome abnormalities in an embryo or fetus are not inherited and have a low chance to occur in future pregnancies. Sometimes, a specific chromosome finding in a miscarriage alerts your doctor to do further studies to investigate the possibility of an underlying genetic or chromosome problem in your family that predisposes you to have miscarriages.

Furthermore, if a chromosome abnormality is identified it can prevent the need for other, sometimes quite costly, studies your doctor might consider to investigate the cause of the miscarriage.

Lastly, knowing the reason for a pregnancy loss can help a couple start the emotional healing process, moving past the question of "Why did this happen to me?".

Chromosome testing can be especially important for patients with repeated miscarriages, as it can either give clues to an underlying chromosomal cause for the miscarriages or rule out chromosome errors as the reason for the miscarriages and allow their doctor to pursue other types of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing may be able to help increase their chances of having a successful healthy pregnancy.

For more information about microarray genetic testing for miscarriage tissue or IVF with PGD visit www.genesecurity.net

About Gene Security Network
Gene Security Network's miscarriage testing is specifically designed for products of conception (POC) analysis to provide as much or more information than a standard karyotype. In order to obtain the most comprehensive results possible, Gene Security Network requests a sample of mother's blood at the same time the POC sample is sent. This allows the results of the miscarriage tissue to be compared with the mother's DNA data to rule out maternal cell contamination.

Ms. Maisenbacher is a board-certified genetic counselor who has worked in pediatric genetics for the past nine years at both the Children's Hospital of Philadelphia and the University of Florida.



Article Source: http://EzineArticles.com/?expert=Melissa_Maisenbacher


http://EzineArticles.com/?Pregnancy-Loss-and-Chromosome-Testing-for-Miscarriages&id=5326846

Monday, April 06, 2015

GIULIANA RANCIC AND SURROGATE MISCARRIAGE

My heart goes out to Giuliana Rancic and her husband.  She has been through so much not only with her struggle to get pregnant, but also her breast cancer diagnosis.  She did happily have a son through a surrogate and tried for another, but sadly her surrogate has miscarried, not once, but twice.  Read more:

She told People magazine: 'We were so optimistic about the last embryo. It was really tough news to be dealt.'   
However, the brunette beauty is keeping things in perspective, considering the long and tumultuous journey that finally resulted in the birth of their son via a surrogate in 2012.
‘If I don’t ever have another kid, I have to remind myself that I’m very fortunate to have what I have,’ she said in an interview with Life & Style after the first miscarriage.
 from: DailyMail

Friday, April 03, 2015

THE THREE MISCARRIAGE RULE: OUTDATED

Miscarriage Over 40, Three Consecutive Miscarriages May Not Be The "Rule"

I have frequently heard about the "three miscarriage rule" which says the cause of miscarriage should be investigated after three pregnancy losses.
 However, that whole concept is somewhat outdated. This article explains more:

SEE ALSO: THINGS YOU MAY NOT KNOW ABOUT MISCARRIAGE (getpregnantover40.com)

Dissatisfied with her obstetrician's response, Arnold set out to find a doctor to do testing to find a cause for her miscarriages. She says doctor after doctor refused, citing the same three-consecutive-miscarriage "rule."

"This theory about three consecutive miscarriages was promulgated back in the 1930s, based on no evidence and no research," Grimes says, adding that even so, there are still doctors who believe it...

...Not only is there controversy about when to test, but also what testing should be done on women who've had miscarriages, and what treatment, if any, should be given based on the results of those tests.

After a woman miscarries, some doctors suggest that a chromosomal analysis be done on the fetal tissue to check for abnormalities.

 www.cnn.com

Wednesday, April 01, 2015

MISCARRIAGE: A PSYCHIC'S PERSPECTIVE

Miscarriage, Karma, and Fear

Yes, I did talk with a psychic when I was trying to conceive and after a number of my miscarriages.
 I even called into a radio show with a local psychic.  The answer was, "yes, you are going to have a baby".
Whether or not you believe in psychic abilities, this site called "askgrace.com" has some interesting perspectives on pregnancy and miscarriage. In this article, "Grace" talks about why a woman may be repeatedly miscarrying:

SEE ALSO: MISCARRIAGE OVER 40 AND THE TOP 10 THINGS YOU MAY NOT KNOW (getpregnantover40.com)

When you call forth a child, you are calling for a great spirit to come to be embodied on Earth. Often, this is a spirit who has been to Earth many times before, and who probably knows you quite well through shared experiences in past lives. These past karmic experiences can bond you together for lifetimes - both from positive, loving experiences, and also from negative, painful ones. If that being has had a lot of painful experiences on Earth, it may be afraid to come back, and so part of this issue with repeated miscarriage may be because this soul is afraid to be born, and is backing out repeatedly.
This soul is also encountering your great fear of loss during pregnancy, which is making matters worse. A fetus feels everything that the mother feels, and these emotions are amplified and magnified a hundred fold. These emotions hit the baby in waves of energy, which either cause the baby to feel loved, comforted, safe and peaceful, or restless, trapped and afraid. It is natural to feel afraid during pregnancy, and it seems that other people cannot resist telling a pregnant woman all kinds of horror stories and things to worry about, but fear does not create an environment that supports life, health and well-being, either for you or your baby. The more peaceful and calm you can remain before, during and after your pregnancy, the better for everyone concerned.
from www.askgrace.com

Sunday, March 29, 2015

INFECTIONS, PREGNANCY, MISCARRIAGE AND FERTILITY

Pregnancy Over 40, Miscarriage Over 40, How Infections May Affect Pregnancy

It seems like pregnant women are more susceptible to infections.  I've heard that your immune system may be "down" a bit because it's the body's way of protecting the baby from attack if your immune system perceives it as a "predator".
    The article addresses everything from colds & flu to vaginal infections & STD's. In rare cases, some of these conditions could lead to pregnancy complications and miscarriage. Read more:

SEE ALSO: INFECTIONS THAT CAUSE INFERTILITY (getpregnantover40.com)


Urinary tract infections (UTI's) are more common during pregnancy than at other times, mostly because of a slowing down of the urine flow on its way from the kidney to the bladder. Around 1 in 25 women get a UTI during pregnancy, the common symptoms being a discomfort or burning sensation on passing urine, an aching pain over the bladder or needing to pass water very frequently. This last symptom is unfortunately very common in pregnancy anyway and is not very reliable in making the diagnosis. If the infection passes up to the kidneys and into the blood stream (pyelonephritis or septicaemia) it causes loin pain, vomiting, a fever and can even start premature labour.
By treating early UTI's, kidney infections and their complications can be prevented. The infection is diagnosed by looking at the urine under a microscope and seeing if a bug can be grown from the sample. This can also confirm which antibiotic is the best to use. A mild infection is treated with a course of antibiotic tablets for at least a week, but a more severe one would need admission to hospital, intravenous antibiotics and rest. After one UTI, further infections are more common and monthly checks on the urine are suggested to see if one is developing even before symptoms appear.
 Thrush
Pregnancy makes a woman more likely to get a thrush infection, most commonly caused by the yeast Candida albicans. This yeast is commonly found in the vagina in up to 16% of non-pregnant women and 32% during pregnancy. It does not always cause symptoms and only requires treatment if it causes troublesome itching, soreness or the typical thick, white discharge. It is more common in second and subsequent pregnancies, in the third trimester, during summer months, following a course of antibiotics and in diabetic women. Treatment with Clotrimazole (Canesten) vaginal suppositories is usually effective. The tablet treatment Fluconazole (Diflucan) is not advised during pregnancy.

from:  (www.womens-health.co.uk)

Sunday, March 22, 2015

MISCARRIAGE: LOSS OF PREGNANCY SYMPTOMS?

When Pregnancy Symptoms Go Away, Is It A Sign Of Miscarriage?

Even though loss of pregnancy symptoms can be a relief physically, it's scary if you have a history of miscarriage.
Sometimes, it means nothing at all, but other times it could be a sign of trouble.
 Most women usually feel some relief of their nausea after the first trimester.  On my successful pregnancy with my daughter, my nausea and vomiting magically went away almost like clockwork when I hit the three month mark.

Some fluctuation in symptoms is normal

I recall when I was pregnant, I had good days and bad days when it came to nausea and vomiting.  I was told by my OB-GYN doctor that it is normal to have some fluctuation in symptoms.
________________
See also  Strange Early Pregnancy Symptoms
________________
When I miscarried a few of my pregnancies, I knew deep down there was a problem when early in the pregnancy, my nausea seemed to vanish overnight.  I would usually start bleeding or spotting right around the same time.  These factors together confirmed my greatest fears.
If you do lose your symptoms suddenly early in your pregnancy, most doctors are willing to do an ultrasound.  There's probably not much that can be done if the pregnancy isn't viable, but sometimes it just helps to know so you can be prepared.  If the pregnancy is continuing normally, it's helpful to put your mind at ease.



Thursday, March 19, 2015

FOURFOLD INCREASE IN STILLBIRTH AFTER IVF/ICSI

Miscarriage Over 40, Stillbirth After IVF and ICSI

I have heard that IVF and ICSI does have a slightly higher rate of newborn complications that naturally conceived pregnancies.
 This article talks about how the stillbirth rate may increase fourfold with this procedure. Read more:


From the article:

Out of a total of 20,166 singleton, first-time pregnancies, 16,525 (82%) were conceived spontaneously after less than 12 months, 2,020 (10%) after more than a year of trying (classified as sub-fertile), 879 (4%) conceived after non-IVF fertility treatment and 742 (4%) conceived after IVF/ICSI. There was a total of 86 stillbirths, giving an overall risk of stillbirth of 4.3 per thousand pregnancies.

SEE ALSO: MISCARRIAGE OVER 40 (getpregnantover40.com)

The risk of stillbirth in women who conceived after IVF/ICSI was 16.2 per thousand; in women who conceived after non-IVF fertility treatment it was 2.3 per thousand; in fertile and sub-fertile women, the risk was 3.7 per thousand and 5.4 per thousand respectively.

Dr Wisborg said: "After adjusting for maternal age, body mass index, education, smoking habits and alcohol and coffee intake during pregnancy we found a significant, four-fold increased risk of stillbirth in women who conceived after IVF/ICSI compared with fertile women. The risk of stillbirth in sub-fertile women and women who conceived after non-IVF fertility treatment was not statistically significantly different from the risk in fertile women. 


 www.medicalnewstoday.com

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